• Telomerase action at the telomere is highly regulated

  2024-01-30

  

  Telomerase action at the telomere is highly regulated; it preferentially elongates the shortest telomeres, and recruitment of the enzyme complex to the telomere occurs in mid-S phase of the cell cycle (Bianchi and Shore, 2007, Britt-Compton et al., 2009, Teixeira et al., 2004, Hemann et al., 2001, T

• br Materials and methods br Results br Discussion In

  2024-01-30

  

  Materials and methods Results Discussion In the present study, we found that SSTR2, SSTR5, and DA2R proteins are expressed in ACTH-positive 92 3 in healthy canine pituitary glands, with particularly high positive cell ratios in the intermediate lobes. Somatostatin has been reported to inhi

• Non steroidal anti inflammatory drugs which include

  2024-01-30

  

  Non-steroidal anti-inflammatory drugs, which include aspirin and ibuprofen, target COX-2 activity to inhibit inflammation. It has been shown that daily use of a nonsteroidal anti-inflammatory drugs is associated with reduced ER-positive breast cancer recurrence in obese and overweight women. More pr

• br Funding The present study was funded by The Scientific

  2024-01-30

  

  Funding The present study was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) within Research Program 1001, unique project number: 214S349. Introduction The apelin receptor, also called APJ or angiotensin receptor-like 1 was first cloned in 1993 due to its stro

• Although the interactions of PhLP with

  2024-01-30

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls Swainsonine signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interacting partner

• Some members from the AAAP family

  2024-01-30

  

  Some members from the AAAP family, namely the AUX1 and the LAX proteins, transport auxin instead of amino acids [48]. While there is some structural relationship between IAA and Trp, the substrate recognition characteristics seem different for these proteins: the auxins do not have any amino group o

• Since non lipoprotein derived free cholesterol is recycled

  2024-01-29

  

  Since non-lipoprotein-derived free cholesterol is recycled from the plasma membrane through the endosomal system through receptor-independent mechanisms, we wanted to determine whether ABCA2 could alter the trafficking of this source of free cholesterol. Our approach was to measure the effect of mob

• AdipoRon acts on the anti diabetic effects

  2024-01-29

  

  AdipoRon acts on the anti-diabetic effects of adiponectin, exhibiting its effect through the activation of AMPK and PPARα pathways via AdipoR1 and AdipoR2, respectively [23]. AdipoR activation is a promising treatment for diabetes, nonalcoholic fatty liver disease, and cardiovascular disease, demons

• Comparison of the GLUT positive plus ACLY

  2024-01-29

  

  Comparison of the GLUT1-positive plus ACLY negative group with the GLUT1-negative plus ACLY positive group indicated no significant difference with respect to disease-free survival and overall survival. However, some obvious differences in histological types were found in their formation. A previous

• The interaction of ATR ATRIP with RPA coated

  2024-01-29

  

  The interaction of ATR-ATRIP with RPA-coated ssDNA is sufficient for ATR-ATRIP recruitment to DNA lesions, but it is not sufficient to fully activate ATR. In response to DNA damage, the heterotrimeric ring-shaped complex 9-1-1 (RAD9-RAD1-HUS1 in humans; Ddc1-Rad17-Mec3 in S. cerevisiae) is loaded at

• br Introduction Arginase deficiency is a rare metabolic diso

  2024-01-29

  

  Introduction Arginase deficiency is a rare metabolic disorder resulting from a loss of arginase 1 (ARG1), the final enzyme in the urea cycle, which is the major pathway for the detoxification of ammonia in terrestrial mammals. ARG1 is expressed most prevalently in hepatocytes and red blood cells.

• br Experimental br Acknowledgment This paper

  2024-01-29

  

  Experimental Acknowledgment This paper was financially supported by the Project Funded by China Postdoctoral Science Foundation (2017T100186), Natural Science Foundation of Liaoning Province (20170540858), General Scientific Research Projects of Department of Education of Liaoning Province (20

• Although the interactions of PhLP with G

  2024-01-29

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls (+)-Bicuculline signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interacting par

• Since at least prospective cohort studies have

  2024-01-29

  

  Since 2005, at least 14 prospective cohort studies have been conducted to clarify inconsistencies in the field, ten of which suggested a direct correlation between antibiotic use and atopy or wheezing later in life [51–60], three found no association [61–63], and one found positive association only

• Voriconazole br Obstructing SNARE zippering Sharma et al dem

  2024-01-29

  

  Obstructing SNARE “zippering” Sharma et al. demonstrated for the first time that in the postmortem AD brains, the level of SNARE complex formation, which is necessary for driving synaptic vesicle fusion at the presynaptic active zone, is significantly reduced [123]. In the absence of changes in e

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