• Autophagy and apoptosis have a

  2025-01-15

  

  Autophagy and apoptosis have a very complex relationship, and the precise mechanism remains to be determined. At present, a large amount of research has confirmed that autophagy can protect the cell from apoptosis in special conditions such as nutrient deficiency or growth factors deprivation; the e

• Given that neither case is

  2025-01-15

  

  Given that neither case is derived from multiplex fluvastatin with affected individuals, principles of Mendelian segregation cannot be applied to implicate the T201S mutation in causing familial CJD. In addition, like many rare gene variants, it is not possible to apply practice guidelines such as

• Interestingly ZIP expression was decreased in dog testes

  2025-01-15

  

  Interestingly, ZIP9 expression was decreased in dog testes after they were implanted with gonadotropin releasing hormone (GnRH) which the authors proposed was due to androgen ablation (Bulldan et al., 2016a). The expression of other members of the ZIP (SLC39A) family has also been shown to be regula

• Daidzein In addition to differential expression of AR protei

  2025-01-15

  

  In addition to differential expression of AR protein primarily in surgical specimens, genetic alterations involving the AR gene have been documented in human Daidzein cancer. Loss of heterozygosity at the AR locus was identified in all 3 informative cases of muscle-invasive bladder tumors, whereas,

• Vinorelbine Platelet derived growth factor PDGF and ciliary

  2025-01-15

  

  Platelet-derived growth factor (PDGF) and ciliary neurotrophic factor (CNTF) are expressed by glial Vinorelbine and are important to neuron survival and the maintenance of oligodendrocytes. These neurotrophic factors contribute to the remyelination process by increasing the proliferation of oligoden

• Glucagon (19-29), human Previous studies to investigate the

  2025-01-15

  

  Previous studies to investigate the functions of AHR in Treg Glucagon (19-29), human have employed a loss-of-function approach, using AHR complete-null mice, or a gain-of-function approach by ligand administration. However, these approaches may confound the interpretation of the results. For example

• The only psychostimulant treatment option in Turkey

  2025-01-15

  

  The only psychostimulant treatment option in Turkey is methylphenidate (Çetin et al., 2015). It is broken down by carboxylase enzyme (CES1) (Sun et al., 2004). From the point of pharmacokinetics, it may be suggested that CES1 gene polymorphisms may be the key responsible factors in patients resistan

• The extent to which GPCR oligomerization is

  2025-01-15

  

  The extent to which GPCR oligomerization is a regulated process still remains unclear. Reported effects of ligands on both GPCR homo- and heteromers are highly variable and depend on GPCR subtypes and the specific ligand used. According to our data, chronic treatment of mice with both paroxetine or

• Several studies have recently used optogenetics to selective

  2025-01-14

  

  Several studies have recently used optogenetics to selectively activate various cholinergic neurons (Jiang et al., 2014). However, most do not explicitly report direct release of GABA from cholinergic fibers, with the exception of our two studies described above (Saunders et al., 2015a, Saunders et 

• Over-the-counter eye drops br Acknowledgements br Introducti

  2025-01-14

  

  Acknowledgements Introduction Thus, damage to the Over-the-counter eye drops may produce severe consequences (National Research Council, 1992). Indeed, though the nervous system has several compensatory and adaptive mechanisms, it is vulnerable to toxic insult, due to its inability to regener

• Kaempferol in apoptosis studies br Materials and methods br

  2025-01-14

  

  Materials and methods Results Discussion CUs, which have been used as traditional medicine for thousands of years in East Asian countries, have the potential to be used for cancer chemoprevention and chemotherapy [17], [18], [19], [20]. CuB is one of the most promising agents as it is repor

• br Introduction Hepatocellular carcinoma HCC is an aggressiv

  2025-01-14

  

  Introduction Hepatocellular carcinoma (HCC) is an aggressive and malignant cancer detected in clinical practice, as it is the third key reason of tumor-related deaths worldwide, with > 800, 000 mortalities every year (Torre et al., 2015). Current treatments for HCC are surgical therapy, liver tra

• Interestingly intermittent high doses of

  2025-01-13

  

  Interestingly, intermittent high doses of AKT inhibitors have been shown to be a more effective strategy both clinically and pre-clinically. High doses appear to be required for induction of apoptosis and intermittent schedules overcome the low therapeutic index of these compounds. This is particula

• Some alterations in the integrity

  2025-01-13

  

  Some alterations in the integrity of cell membranes caused by toxic agents can be determined by measuring certain enzymes released by damaged cells [8]. The cholinesterases, for example, catalyze the hydrolysis of Vacquinol-1 (ACh) in choline and acetic acid. Theses enzymes are divided into two typ

• LOXs and CYPs are a series of

  2025-01-10

  

  LOXs and CYPs are a series of iron-containing enzymes that metabolize arachidonic ARC029 to form biologically active products, such as epoxyeicosatrienoic acids (EETs) hydroperoxyeicosatetraenoic acids (HETEs), prostaglandins, leukotrienes and thromboxanes [6]. Among these mediators, 12/15LOX has g

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