• br Introduction Epidermal growth factor receptor EGFR activa

  2021-05-17

  

  Introduction Epidermal growth factor receptor (EGFR)-activating-mutant non-small cell lung cancer (NSCLC) often initially responds well to EGFR tyrosine kinase inhibitors (TKIs) (Haber et al., 2011); however, the disease almost always recurs about 10–13 months of therapy. Analysis of clinical spe

• br Acknowledgements This work was supported by

  2021-05-17

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (No. 81400241). Introduction Fluoride, as a member of the halogen group of elements, naturally existed in water, soil, animals, and plants around the world (Singh et al., 2018), and it is present in trace

• DNA bound Ku proteins recruit

  2021-05-17

  

  DNA-bound Ku proteins recruit DNA-PKcs; and thereby translocate into the duplex by one helical turn, leaving DNA-PKcs near the DNA terminus to assist in tethering the broken ends together [25]. In addition to keeping the DSBs in close proximity, DNA-PKcs may prevent exonucleolytic degradation of the

• Funding sources This study was funded by

  2021-05-17

  

  Funding sources This study was funded by European Community’s Seventh Framework Programme under grant agreement No. 305662 (Project: Community-based scheduled screening and treatment of malaria in pregnancy for improved maternal and infant health: a cluster-randomized trial ‘COSMIC’). Acknowledg

• That DGAT mediated hepatic steatosis

  2021-05-17

  

  That DGAT-mediated hepatic steatosis did not lead to insulin resistance was clearly demonstrated in Liv-DGAT2-low mice by their normal blood glucose and plasma insulin levels, normal glucose and insulin tolerance, normal insulin sensitivity by hyperinsulinemic-euglycemic clamp studies, and normal he

• BV6 Uracil residues incorporated into DNA

  2021-05-17

  

  Uracil residues incorporated into DNA exist transiently since they are subject to removal by the multi-step uracil-initiated DNA BV6 excision repair (BER) process [2], [14]. In E. coli, uracil-DNA BER is initiated by uracil-DNA glycosylase (Ung), which catalyzes the hydrolytic cleavage of the N-glyc

• br Endothelial mechanotransduction br Apoptosis

  2021-05-17

  

  Endothelial mechanotransduction Apoptosis Death associated protein kinase Conclusion DAPK is localized to the BAMB-4 network, and promotes actomyosin contractility. DAPK stabilizes stress fibers by phosphorylation of MLC (Bialik et al., 2004, Kuo et al., 2003). In endothelial cells DAPK

• br Conclusion In vivo pharmacokinetic studies showed that da

  2021-05-17

  

  Conclusion In vivo pharmacokinetic studies showed that dasatinib monohydrate pretreatment significantly decreased the blood level of CsA in rats, which was most probably due to the induction of CYP3A2 isoenzymes. The nilotinib pre-treatment had no significant effects on cyclosporine pharmacokinet

• p Kip is a critical component of

  2021-05-17

  

  p27Kip1 is a critical component of the cell cycle machinery [15]. As an inhibitor of cyclin E-Cdk2, p27Kip1 plays a pivotal role in controlling cell proliferation, S-phase entry, and G1-phase exit during development and tumorigenesis [16]. p27Kip1 is predominantly regulated via posttranslational mod

• br Conflict of interest br Acknowledgments Part

  2021-05-17

  

  Conflict of interest Acknowledgments Part of this work was supported by Institut Francais en Egypte, and the Academy of Scientific Research and Technology in Egypt under the frame of “Imhotep Project N°: 31681XL” and “STDF/IFE project N° 30630″ Introduction NSAIDs play an important role in

• COMT protein expression was investigated as a potential

  2021-05-17

  

  COMT protein Punicalin synthesis was investigated as a potential mechanism by which tolcapone may differentially affect male and female P and Wistar rats. COMT protein levels in the PFC were lower in P rats compared to Wistars but female P rats expressed greater levels of COMT in the PFC relative t

• Introduction br CK in the Regulation of Hh Pathway

  2021-05-17

  

  Introduction CK1 in the Regulation of Hh Pathway CK1 was initially identified as a negative regulator of Hh signaling at the level of transcription factor Ci by genetic studies in Drosophila and genome-wide RNAi screen in Drosophila cultured SQ 29,548 mg (Jia et al., 2005, Lum et al., 2003, Pric

• Several large scale clinical studies

  2021-05-17

  

  Several large-scale clinical studies have set out with the common goal to further understand the cognitive impact of menopause and hormone therapies taken by women (Gleason et al., 2015, Greendale et al., 2011, Karlamangla et al., 2017, Rapp et al., 2003, Shumaker et al., 2003). Only one human study

• ATP binding cassette transporters such as ABCA and ABCG

  2021-05-17

  

  ATP-binding cassette transporters such as ABCA1 and ABCG1 are expressed on cell membranes to transport cholesterol from SR 2595 to HDL. These transporters help to improve RCT and reduce atherosclerosis. ABCA1 and ABCG1 gene expression are primarily induced by the stimulation of liver X receptor/ret

• br Introduction Vein graft implantation into

  2021-05-17

  

  Introduction Vein graft implantation into the arterial environment for surgical bypass is the gold standard to treat severe cardiovascular occlusive disease. After placement of a vein into the higher pressure, flow, and oxygen tension of the arterial circulation, the vein adapts to the arterial e

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