• br Conclusions br Introduction The

  2019-11-04

  

  Conclusions Introduction The terms endocrine active and endocrine disruptive have been used to describe an ever-expanding list of naturally-occurring and synthetic compounds that interact with mammalian hormonal systems, and in particular, the reproductive system. These compounds have been ass

• br Materials and Methods br Acknowledgements Authors would l

  2019-11-04

  

  Materials and Methods Acknowledgements Authors would like to thank Mr. Pritam Naskar and Mr. Dibya Mukherjee for their help. Authors also acknowledge the help of Mr. Barun Mahata and Dr. Kaushik Biswas, Division of Molecular Medicine, Bose Institute, for human cDNA samples. P.A.B. and A.B.D. w

• The dihydroxynaphthalene derived substrates a a

  2019-11-02

  

  The 2,3-dihydroxynaphthalene-derived substrates 18a, 20a and 22a (Table 2) allowed only moderate growth of all members of the panel of microorganisms suggesting that these substrates were inhibitory to some extent. Strong growth of the Gram-negative microorganisms and moderate growth of the Gram-pos

• The potent estrogen EE induced a decrease in CYP

  2019-11-02

  

  The potent 4-P-PDOT EE2 induced a decrease in CYP2C11 activity (reduction in 2α-OH and 16α-OH testosterone) and protein at the 200 ppb dose and in this respect was similar to nonylphenol and genistein. This result agrees qualitatively with the results of Hallstrom et al. (1996) who exposed male rat

• U 18666A The expression of cytokine inducible genes is

  2019-11-02

  

  The expression of cytokine-inducible genes is mediated by a number of components within the cell. It has been shown that Jak2 and the Ras/Raf/MAP kinase signaling cascades are required for the expression of DUB-1[9], [29]. However, the enhancer domain of DUB-1 lacks a consensus sequence for Stat bin

• br DDR receptor and MMP expression

  2019-11-02

  

  DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix of mature articular cartilage once the collagen gets disrupt

• Cell lines which possess microglial

  2019-11-02

  

  Cell lines which possess microglial or neuronal properties are uncomplicated and convenient in vitro models for studying 2665 injury at the cellular and molecular levels. Microglial BV-2 cells are derived from the immortalized mouse microglia and exhibit many of the morphological, phenotypical and f

• The physiological role of the

  2019-11-02

  

  The physiological role of the UCNs in the regulation of the HPA axis is still under debate (Fekete and Zorrilla, 2007, Suda et al., 2004). UCN 1 was proved to increase the plasma ACTH and corticosterone levels in rats (Bagosi et al., 2014, Vaughan et al., 1995), whereas UCN 2 and UCN 3 were shown to

• Previous studies have demonstrated the role of the

  2019-11-02

  

  Previous studies have demonstrated the role of the COMT Val158Met in response to positive and negative emotional stimuli (Bouhuys et al., 1999, Cohn et al., 2009), a fundamental process involved in well-being (Diener et al., 2009a, Diener et al., 1999, Gross and John, 2003). A handful of studies rep

• Antioxidants such as SFN have been

  2019-11-02

  

  Antioxidants such as SFN have been proposed to be chemopreventive agents to inhibit, delay or reverse the development of cancer (Bayat Mokhtari et al., 2018). SFN was shown in breast epithelial cell culture to suppress oxidative metabolism of E2/E1 and thus protect against estrogen-mediated DNA dama

• To elucidate the potential mechanism

  2019-11-01

  

  To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine panx and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells were arrested in G1 phase of the

• Additionally of outmost important is the location of

  2019-11-01

  

  Additionally, of outmost important is the location of the different CpG islands in relation to the transcription starting site (TSS) of the promoter as well as their interaction with transcription activators or repressors. It has been shown that methylation at the downstream region of the TSS in the

• PI K Akt signaling pathway is known in

  2019-11-01

  

  PI3K/Akt signaling pathway is known in modulating cell apoptotic process (Saurus et al., 2015). To study the contribution of PI3K/Akt signaling pathway in ERRγ-mediated anti-apoptotic effect in podocytes, we examined phosphorylation of Akt and expression of PI3K subunits p110α and p85α via qRT-PCR a

• br Funding br Conflict of interests br Introduction

  2019-11-01

  

  Funding Conflict of interests Introduction DAG is generated by the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) by PtdIns-specific phospholipase C (PLC) enzymes [1]. Remaining in the membrane, it binds proteins with cysteine-rich, C1 domains, and activates several of

• Studies of Jelski and Szmitkowski

  2019-11-01

  

  Studies of Jelski and Szmitkowski show that differences of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity between PNU-120596 of many cancers and healthy tissue may be one of the factors intensifying carcinogenesis [7]. Moreover, changes of ADH and ALDH activity in cancer cel

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